84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 49 4-Benzyloxycarbonyl-1-(4-methyl-5-isoquinolinesulfonyl)-2-methylpiperazine To a solution of 1-benzyloxycarbonyl-3-methylpiperazine (5.09 g) in chloroform (150 ml), a solution of triethylamine (3.0 ml) and 4-methyl-5-isoquinolinesulfonyl chloride (6.05 g) in chloroform (50 ml) was gradually added dropwise. After completion of the dropwise addition, the resultant mixture was continuously stirred at 60C for 20 hours.The reaction mixture was washed first with water (100 ml x 2) and then with a saturate aqueous solution of sodium chloride (100 ml), and was then dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (chloroform), whereby 3.95 g of the target compound were obtained. 1H-NMR (270 MHz, CDCl3) delta: 9.15(1H,s), 8.54(1H,s), 8.37(1H,dd,J=7.92,1.32Hz), 8.17(1H,dd,J=7.92,1.32Hz), 7.61(1H,t,J=7.59Hz), 7.36(5H,m), 5.17(2H,dd,J=14.85,12.21Hz), 4.05-4.18(3H,m), 3.33-3.55(3H,m), 3.04(3H,s), 1.34(3H,d,J=6.60Hz)., 84477-85-0
As the paragraph descriping shows that 84477-85-0 is playing an increasingly important role.
Reference£º
Patent; Hidaka, Hiroyoshi; EP1074545; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics