74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
74879-18-8, Step D: A mixture of 7-fluoro-3-(4-methylthiazol-2-yl)-2H-chromen-2-one (100 mg, 0.38 mmol), (S)-2-methylpiperazine (46 mg, 0.46 mmol) and DMSO (600 uL) was heated at 80 C for 15 h. The reaction mixture was diluted in an aqueous saturated NaHC03 solution and filtered. The collected material was purified by silica gel column chromatography (10% MeOH in CH2CI2), followed by trituration with 1 : 1 hexane/acetone to yield the title compound (103 mg, 79%) as a yellow solid: m.p. 194-199 C; MS m/z 342.2 [M+H]+; 1H NMR (500 MHz, DMSO- d6): delta 8.80 (1H, s), 7.75 (1H, d, J= 9 Hz), 7.32 (1H, m), 7.06 (1H, dd, J= 9 Hz, 2.5 Hz), 6.91 (1H, d, J= 2.5 Hz), 3.88 (2H, t, J= 11 Hz), 2.96 (1H, d, J= 12 Hz), 2.81 (1H, td, J= 12 Hz, 3 Hz), 2.72 (2H, m), 2.45 (4H, m), 2.36 (1H, br s), 1.04 (3H, d, J= 6.5 Hz).
The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PTC THERAPEUTICS, INC.; F. HOFFMANN-LA ROCHE AG; WOLL, Matthew G.; CHEN, Guangming; CHOI, Soongyu; DAKKA, Amal; HUANG, Song; KARP, Gary Mitchell; LEE, Chang-Sun; LI, Chunshi; NARASIMHAN, Jana; NARYSHKIN, Nikolai; PAUSHKIN, Sergey; QI, Hongyan; TURPOFF, Anthony A.; WEETALL, Marla L.; WELCH, Ellen; YANG, Tianle; ZHANG, Nanjing; ZHANG, Xiaoyan; ZHAO, Xin; PINARD, Emmanuel; RATNI, Hasane; WO2013/101974; (2013); A1;,
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