5308-25-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.
Under nitrogen protection, 4-fluorobenzoic acid methyl ester (3.0 mL, 20.69 mmol) was dissolved in 20 mL DMSO,K2CO3 (5.718 g, 41.38 mmol) was added sequentially,N-ethylpiperazine (1.93 mL, 24.83 mmol). 120 C overnight,The reaction was cooled to room temperature, and the mixture was partitioned between ethyl acetate and saturated brine (50 mL). The aqueous layer was extracted with ethyl acetate (50 mL ¡Á 3), and the combined organic layers were washed with saturated sodium chloride,Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure, and the residue was subjected to silica gel column chromatography (dichloromethane / methanol = 10/1) to obtain 4.405 g of a white solid, yield 85.8%.
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Fudan University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Li, Yingxia; Geng, Meiyu; Liu, Jing; Ding, Jian; Zhang, Wei; Ai, Jing; (20 pag.)CN106032359; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics