With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
Yellow solid; IR (KBr, cm-1): v 3284 (-NH), 3069-3078 (-CH str.), 2223 (CN), 1255 (C-O-C), 836 (s-triazine C-N str.), 749 (C-F). 1H NMR (400 MHz, Me2SO-d6): delta 9.22 (s, 1H, -NH, s-triazine to amino-benzonitrile linkage), 8.10 (dd, J = 1.7, 1.1 Hz, 1H, C5 proton of coumarin), 7.61-7.64 (m, 1H, coumarin), 7.45 (t, J = 8.5 Hz, 1H, C6 proton of coumarin), 7.33-36 (m, 1H, coumarin), 7.29-6.90 (9H, m, Ar-H), 3.87 (4H, br s, piperazine), 3.48 (4H, br s, piperazine). 13C NMR (100 MHz, Me2SO-d6): delta 175.4 (1C, C-6, s-triazine, C-N at piperazine linkage), 167.2 (1C, C-4, s-triazine, C-O-C at quinoline linkage), 165.9, 163.8 (2C, 1C at C-2, s-triazine, C-NH at benzonitrile moiety and 1C of CO), 152.9 (1C of C-9, coumarin), 148.3-119.6 (19C, Ar. C including C-CF3 at 129.7 and CF3 at 126.1), 106.1 (1C, CN), 97.4 (1C, -C-CN), 48.6, 46.2 (4C, piperazine ring carbon atoms). 19F NMR (400 MHz, CDCl3): delta -65.33 (3F, s, 4-CF3)., 30459-17-7
30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Patel, Rahul V.; Kumari, Premlata; Rajani, Dhanji. P.; Chikhalia, Kishor H.; Journal of Fluorine Chemistry; vol. 132; 9; (2011); p. 617 – 627;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics