With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.150407-69-5,(S)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
A mixture of (S)- 1 -((benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2- carboxylic acid (1 g, 2.744 mmol, 1.0 eq), 6-(trifluoromethyl)pyridin-2-amine (667 mg, 4.116 mmol, 1.5 eq), and EDCI (1.58 1 g, 8.232 mmol, 3.0 eq) in pyridine (50 mL) was stirred at r.t. for 6 h. The mixture was concentrated and purified by chromatography on silica gel column (PE/EA = 5/1, v/v) to give the crude (S)-1-benzyl 4-tert-butyl 2-((6-(trifluoromethyl)pyridin- 2-yl)carbamoyl)piperazine-1,4-dicarboxylate (900 mg, 65%) as a brown solid.
150407-69-5, The synthetic route of 150407-69-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LIFESCI PHAMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (241 pag.)WO2017/98328; (2017); A2;,
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