5625-67-2, Piperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The 1-(4-fluorophenyl)-2-piperazinone used in the above procedure was prepared as follows:A mixture of 2-piperazinone (1.5 g, 15.0 mmol), 1-fluoro-4-iodobenzene (3.5 ml, 30.0 mmol), copper(l) iodide (0.57 g, 3.0 mmol), N,N’-dimethyl-1 ,2-cyclohexanediamine (0.95 ml, 6.0 mmol) and potassium phosphate (9.5 g, 44.9 mmol) in 1 ,4-dioxane (20 ml) was heated at reflux (1 10 0C) under argon for 24 hours. The mixture was allowed to cool to room temperature and then diluted with methanol, and filtered through a pad of celite, washing with methanol. The filtrate was evaporated in vacuo and the resulting residue was dissolved in dichloromethane and 0.88 aqueous ammonia solution (~5ml) in water (~30ml). The mixture was then extracted into dichloromethane (x3), and the combined organic extracts were washed with water (x1 ) and dried over magnesium sulphate. The solvent was evaporated in vacuo and the crude product was purified further by column chromatography on flash-silica gel, eluting with 0-10percent methanol in dichloromethane. The relevant fractions were combined and the solvent was evaporated in vacuo. The residue was purified by SCX, eluting first with methanol and then with 2M ammonia in methanol. The basic fractions were combined and the solvent was evaporated in vacuo to give crude product which was purified again by flash-silica gel column chromatography, eluting with 20percent 2M ammonia in methanol in dichloromethane, to give 1-(4-fluorophenyl)-2- piperazinone (560 mg) as a colourless solid. LC/MS [M+H]+ = 195., 5625-67-2
5625-67-2 Piperazin-2-one 231360, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/53459; (2009); A1;,
Piperazine – Wikipedia
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