With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.
1.0 g of 1-(2,4-fluorophenyl)-piperazine (Compound A-1c), 15 mL of acetic acid was added to the sealed reactor, followed by the addition of 3 mL of hydrated formaldehyde, 1.0 g of sodium acetate;The reaction mixture was warmed to 60 C and stirred for 18 hours;The residue obtained was purified to give 1-(2,4-fluorophenyl)-4-methylpiperazine (A-c) (0.92 g, yield 86%)., 115761-79-0
As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.
Reference£º
Patent; Chengdu Ruizhi Chemical Co., Ltd.; Zhou Zhen; Zhu Mingkui; Li Kun; (9 pag.)CN109897014; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics