115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,115619-01-7
In a RB flask fitted with rubber septum and Argon baloon, 2-chloro-4-(2-(3-nitrophenyl)- 5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrimidine (0.140 mmol), p-TSA (0.279 mmol) and 4-(4-ethylpiperazin- 1 -yl)aniline (0.168 mmol) were taken in NMP. The reaction mixture was heated at 110 C for 12-14 h. The reaction mixture was cooled, diluted with saturated aqueous NaHC03 and extracted with ethyl acetate. The combined organic layers were washed with water, dried over anhydrous Na2S04 and concentrated. The crude reaction mixture was purified by silica gel column chromatography. Yield = 87% (0779) XH NMR (CDC13, 300 MHz) delta: 8.33 (s, 1H), 8.30 (d, / =4.8Hz, 1H), 8.11 (d, / =7.8Hz, 1H), 7.61 (d, =7.5Hz, 1H), 7.43 (t, J =7.8, 8.1Hz, 1H), 7.25 (d, =8.7Hz, 2H), 6.96 (s, 1H), 6.82 (d, =8.4Hz, 1H), 6.56 (d, =5.1Hz, 1H), 3.17 (m, 2H), 3.03 (m, 2H), 2.92 (m, 2H), 2.65 (m, 4H), 2.52 (m, 4H), 1.27 (s, 2H), 1.16 (t, = 6.9, 7.2Hz, 3H). Mass: 527 (M+l)
The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; ROYCHOWDHURY, Abhijit; SHARMA, Rajiv; GADEKAR, Pradip, Keshavrao; URUNKAR, Ganesh, Devidas; SEELABOYINA, Balapadmasree; DEKA, Nabajyoti; DAWANGE, Mahesh, Balasaheb; B-RAO, Chandrika; KHANNA, Smriti; WO2015/128698; (2015); A1;,
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