13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1 : 4-(4-Acetylpiperazin-l-yl)benzaldehyde To a solution of 4-fluorobenzaldehyde (5 g, 40.2 mmol) in N,N-dimethylformamide (130 mL) was added potassium carbonate (8.35 g, 60.4 mmol) and 1-piperazin-l-ylethanone (10.3 g, 80.5 mmol) and the reaction was stirred at 130 C for 16 hours. The reaction was then cooled to ambient temperature, diluted with EtOAc and washed with water (x2) and brine. The organic layer was then dried with MgSC>4, concentrated and purified by silica gel column chromatography (0-10% methanol in dichloromethane) to give 4-(4- acetylpiperazin-l-yl)benzaldehyde (5.96 g, 64% yield). LCMS (m/z) ES+ 233 [M+l]+.
13889-98-0, The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; FAUBER, Benjamin; RENE, Olivier; WO2013/92941; (2013); A1;,
Piperazine – Wikipedia
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