122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-(methylsulfonyl)-4-(3-nitrophenoxy)pyrazolo[l ,5-a][ l ,3,5]triazine (7, 0.25 g, 0.74 mmol), 2-methoxy-4-(4-methylpiperazin- l -yl)aniline (8, 0.164 g, 0.74 mmol), Cul (14 mg, 0.074 mmol), L- proline (17 mg, 0.14 mmol) and K3P04 (0.474 g, 2.2 mmol) in DMF (5 mL) was stirred at 80 C for overnight. Reaction was monitored by TLC and LCMS. After completion of the reaction, water was added and extracted with ethyl acetate. Organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure. Crude product was purified by column chromatography using 3% MeOH-DCM to afford N-(2-methoxy-4-(4-methyIpiperazin- l -yl)phenyl)- 4-(3-nitrophenoxy) pyrazolo[ l ,5-a][ l ,3,5]triazin-2-amine (9, 0.15 g, 42%). NMR (400 MHz, CDjOD): delta 8.20-8.18 (m, 2H), 8.10 (s, 1 H), 7.70-7.45 (m, 3H), 6.65 (s, 1 H), 6.40-6.30 (d, 1 H), 6.25 (s, 1 H), 3.95 (s, 3H), 3.30-3.20 (t, 4H), 2.70-2.60 (t, 4H), 2.32 (s, 3H).
122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun; WO2011/79231; (2011); A1;,
Piperazine – Wikipedia
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