With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 10 (0.17mmol, 1.0eq.), TEA (10.0eq.) and corresponding amine (5.0eq.) in ethanol (5mL) was stirred at reflux overnight. The reaction solution was evaporated. The residue was purified by silica gel column chromatography (dichloromethane/methanol/ammonium hydroxide=50/1/1) to give the desired product
20327-23-5, As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.
Reference£º
Article; Lin, Yu; Li, Zhanhui; Xu, Chen; Xia, Kaijiang; Wu, Shuwei; Hao, Yongjin; Yang, Qing; Ma, Haikuo; Zheng, Jiyue; Luo, Lusong; Zhu, Fang; He, Sudan; Zhang, Xiaohu; Bioorganic Chemistry; vol. 99; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics