Month: January 2021

655225-01-7, tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,655225-01-7

The compound obtained in Example 138-5 (141 mg, 0.54 mmol) was dissolved in DMF (2.8 ml). Thereto cesium carbonate (209 mg, 0.64 mmol), tert-butyl 4- (2-bromomethyl) piperazine-1-carboxylate (317 mg, 1.08 mmol), potassium iodide (179 mg, 1.08 mmol) was added to 70 and the mixture was stirred overnight at . After the reaction, the solvent was evaporated. The residue was purified by silica gel column chromatography (Chromatorex NH 10 g, hexane / ethyl acetate) to give the title compound (246 mg, 95.8percent) as a yellow oil.

The synthetic route of 655225-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yakult Honsha Co., Ltd.; University of Occupational and Environmental Health; Ono, Masahiro; Kobayashi, Tsuneyuki; Yamazaki, Ryuta; Haibara, Hirotake; Nishiyama, Yukiko; Hokkyo, Atsuko; Nishiyama, Hiroyuki; Kurita, Akinobu; Matsuzaki, Ken; Kono, Kimitoshi; Izumi, Hiroto; (215 pag.)JP2016/124812; (2016); A;,
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170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 2a (1.0 g, 3.6 mmol) in dichloromethane (30 mL)was added 1,1?-thiocarbonyldiimidazole (1.2 g, 7.2 mmol) at roomtemperature. The reaction mixture was stirred at room temperature for1 h. The solvent was removed in vacuo and the residue was purified bysilica gel chromatography (Developing solvent: petroleum ether (PE)/ethyl acetate (EA)=20/1) to give 3a (1.0 g, yield 87.2%). 1H NMR(300 MHz, DMSO-d6): delta 1.42 (s, 9H), 3.08-3.23 (m, 4H), 3.37-3.52 (m,4H), 6.96 (d, J=8.7 Hz, 2H), 7.29 (d, J=8.7 Hz, 2H)., 170911-92-9

The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bao, Jiyin; Liu, Haichun; Zhi, Yanle; Yang, Wenqianzi; Zhang, Jiawei; Lu, Tao; Wang, Yue; Lu, Shuai; Bioorganic Chemistry; vol. 94; (2020);,
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3022-15-9, Piperazine-2-carboxylic acid dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 1 : 1 ,4-Bis{[(1 ,1 -Dimethylethyl)oxy]carbonyl}-2- piperazinecarboxylic acidTo a solution of 2-piperazinecarboxylic acid (10 g) dihydrochloride in methanol (500 mL) at 0 C was added triethylamine (28.8 mL) dropwise via a dropping funnel. After addition, the solution was stirred for 30 minutes and then cooled to 0 C before addition of di-tert-butyl dicarbonate (27.4 mL). The reaction was stirred for 18 h at room temperature. The reaction mixture was concentrated under vacuum and then partitioned between ethyl acetate (500 ml) and water (500 mL). The organic phase was washed with further water (500 mL) and then brine (300 mL) before it was dried (Na2S04), filtered and the solvent removed under vacuum to give an oil of 3g, which was discarded. The aqueous layer was acidified to pH 2 with 5M HCI and then extracted with ethyl acetate (2 x 700 mL). The organic phase was dried (Na2S04), filtered and the solvent removed under vacuum to give the title compound as a white solid (14.58 g).LCMS (low pH) RT 0.98 min : m/z (ES) 331 [M+H]+, 3022-15-9

The synthetic route of 3022-15-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; NORTON, David; ANDREOTTI, Daniele; WARD, Simon E; PROFETA, Roberto; SPADA, Simone; PRICE, Helen Susanne; WO2012/98400; (2012); A1;,
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109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-methyl-piperazine (2.0 g, 0.02 mol) and triethylamine (6 mL) in methylene chloride (15 mL) at 0 C. was added (Boc)2O (4.14 g, 0.019 mol) dropwise. The mixture was stirred at room temperature for 1 hour, and then the solvent was removed by rotary evaporation. The residue was dissolved in methylene chloride, washed with saturated sodium bicarbonate and brine, dried over Na2SO4, and purified by column chromatography on silica gel (DCM:MeOH:Et3N=75:1:0.2) to give an white solid (1.65 g, 42%). LC-MS (ESI) m/z: 201 (M+1)+.

109-07-9, As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-60-6,(R)-1-Boc-Piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

PREPARATIVE EXAMPLE 6; The tricyclic alcohol [] (5.6 gm, 17.33 mmol) was dissolved in CH2Cl2 (56 mL) and SOCl2 (2.46 mL) was added while stirring under a dry N2 atmosphere. After 5 hrs. the tlc was checked ( by adding an aliquot of the reaction mixture to 1N NaOH and shaking with CH2Cl2 and checking the CH2Cl2 layer by tlc using 50percent EtOAc/Hexanes as the eluent). The mixture was evaporated to give a gum which was evporated from dry toluene twice and once from CH2Cl2 to give a foamy solid. The resulting chloro-tricyclic compound was dissolved in dry DMF (100 mL) and the title compound from Preparative Example 5 (3.98 gm) was added followed by triethylamine (12.11 mL) and the mixture stirred at ambient temperature under a nitrogen atmosphere. After 24 hours, the reaction mixture was concentrated and the residue dissolved in EtOAc (200 mL) and washed with brine. The brine layer was extracted with EtOAc (2X) and the combined organics were dried over MgSO4, filtered, and evaporated to give a foamy solid. The solid was chromatographed on a 1 1/2″ X 14″ column of silica gel eluting with 2L of 0.4percent 7N MeOH/NH3:CH2Cl2, 6L of 0.5percent 7N MeOH/NH3:CH2Cl2, 2L of 0.65percent 7N MeOH/NH3:CH2Cl2, 2L of 0..8percent 7N MeOH/NH3:CH2Cl2, 4L of 1percent 7N MeOH/NH3:CH2Cl2, 2L of 3percent 2N MeOH/NH3:CH2Cl2, 2L of 5percent 2N MeOH/NH3:CH2Cl2, 2L of 10percent 2N MeOH/NH3:CH2Cl2, 2L of 15percent 2N MeOH/NH3:CH2Cl2, 4L of 20percent 2N MeOH/NH3:CH2Cl2 to obtain 4.63 gm of final product.

278788-60-6, 278788-60-6 (R)-1-Boc-Piperazine-2-carboxylic acid 24820285, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; EP1140904; (2005); B1;,
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Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,115619-01-7

In a RB flask fitted with rubber septum and Argon baloon, 2-chloro-4-(2-(3-nitrophenyl)- 5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrimidine (0.140 mmol), p-TSA (0.279 mmol) and 4-(4-ethylpiperazin- 1 -yl)aniline (0.168 mmol) were taken in NMP. The reaction mixture was heated at 110 C for 12-14 h. The reaction mixture was cooled, diluted with saturated aqueous NaHC03 and extracted with ethyl acetate. The combined organic layers were washed with water, dried over anhydrous Na2S04 and concentrated. The crude reaction mixture was purified by silica gel column chromatography. Yield = 87% (0779) XH NMR (CDC13, 300 MHz) delta: 8.33 (s, 1H), 8.30 (d, / =4.8Hz, 1H), 8.11 (d, / =7.8Hz, 1H), 7.61 (d, =7.5Hz, 1H), 7.43 (t, J =7.8, 8.1Hz, 1H), 7.25 (d, =8.7Hz, 2H), 6.96 (s, 1H), 6.82 (d, =8.4Hz, 1H), 6.56 (d, =5.1Hz, 1H), 3.17 (m, 2H), 3.03 (m, 2H), 2.92 (m, 2H), 2.65 (m, 4H), 2.52 (m, 4H), 1.27 (s, 2H), 1.16 (t, = 6.9, 7.2Hz, 3H). Mass: 527 (M+l)

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; ROYCHOWDHURY, Abhijit; SHARMA, Rajiv; GADEKAR, Pradip, Keshavrao; URUNKAR, Ganesh, Devidas; SEELABOYINA, Balapadmasree; DEKA, Nabajyoti; DAWANGE, Mahesh, Balasaheb; B-RAO, Chandrika; KHANNA, Smriti; WO2015/128698; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

Preparation of the Final Compounds: (cr) 3-Z-[1-(4-(N-(4-methyl-piperazin-1-yl-methylcarbonyl)-N-methyl-amino)-anilino)-methylene]-6-ethylcarbamoyl-2-indolinone 160 mg 3-(1-hydroxy-methylene)-6-ethylcarbamoyl-2-indolinone (starting material VIII) and 543 mg N-[(4-methyl-piperazin-1-yl)-methylcarbonyl]-N-methyl-p-phenylendiamine are dissolved in 3 ml of tetrahydrofuran, 506 ml trimethylsilylimidazole are added and the mixture is stirred for 25 minutes at 170 C. in a microwave oven. After cooling the solvent is evaporated and the residue is purified over an aluminum oxide column (activity 2-3) with methylene chloride/ethanol (19:1) as eluant. The residue is recrystallized from ether and vacuum-dried at 80 C. Yield: 0.17 g (52% of theory), Rf value: 0.60 (aluminum oxide, methylene chloride/methanol=9:1) Melting point: 255-260 C. C26H32N6O3 Mass spectrum: m/z=477 [m+H]+, 262368-30-9

As the paragraph descriping shows that 262368-30-9 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; US2006/142373; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

A mechanically-stirred solution of 1-(2-hydroxyethyl)piperazine (10.0 g, 9.4 mL, 0.07 mol) in 30 mL of deionized water is cooled to 0 C. Then portions of 4N sodium hydroxide (total 28 mL) and portions of benzyl chloroformate (18.8 g, 15.7 mL, 0.11 mol) are added over 15 minute periods, keeping the temperature at 0 C. to 5 C. At the end of the additions, 4N sodium hydroxide solution is added to bring the pH of the reaction mixture to 10. After 1 hour dichloromethane (200 mL) is added and the layers are separated. The organic solution is dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 1-(2-hydroxyethyl)-4-carbobenzyloxypiperazine., 103-76-4

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mallinckrodt Medical, Inc.; US5554749; (1996); A;,
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934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 12 (0.3 mmol) and PyBOP (0.45 mmol) in THF (20 mL) was stirred for 10 min. Afterwards, the corresponding amine (0.34 mmol) and DIPEA (0.76 mmol) were given to the mixture and stirred overnight at RT. The crude mixture was evaporated, the product was dissolved in EtOAc, washed with Na2CO3 solution, and dried over Na2SO4. After evaporation, the product was purified by column chromatography (eluent: CHCl3/MeOH).

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Sauer; Skinner-Adams; Bouchut; Chua; Pierrot; Erdmann; Robaa; Schmidt; Khalife; Andrews; Sippl; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 22 – 40;,
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548762-66-9, (2S,5R)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of tert-butyl (2S,5R)-2,5-dimethylpiperazine-1-carboxylate (1.5 g, 7. mmol) in acetonitrile (15 mL) was added DIPEA (3.7 mL, 21 mmol) and methyl 2-bromo-2-(4-fluorophenyl)acetate (1.9 g, 7.7 mmol). The reaction mixture was heated up to 85 C over 10 min and was stirred for 16 h. The reaction mixture was concentrated under reduced pressure to obtain a brown gummy solid. The crude compound was purified by flash chromatography (using 24 g silica gel column; using 5 % -10 % ethylacetate/ Pet. ether) to obtain tert-butyl (2S,5R)-4-(1-(4-fluorophenyl)-2-methoxy-2- oxoethyl)-2,5-dimethylpiperazine-1-carboxylate (2.35 g, 6.18 mmol, 88% yield) as brown solid. LCMS: m/z, 379.3 (M-H); rt 1.13 min; Column: Waters Acquity UPLC BEH C18 (2.1 x 50 mm) 1.7 mm, Mobile phase A: 10 mM ammonium acetate:acetonitrile (95:5); Mobile phase B: 10 mM ammonium acetate:acetonitrile (5:95), Gradient = 20-90 % B over 1.1 minute, then a 0.6 minute hold at 90 % B; Temperature: 50 C; Flow rate: 0.7 mL/min; Detection: UV at 220 nm., 548762-66-9

As the paragraph descriping shows that 548762-66-9 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; CHUPAK, Louis S.; DARNE, Chetan Padmakar; DING, Min; GENTLES, Robert G.; HUANG, Yazhong; KAMBLE, Manjunatha Narayana Rao; MARTIN, Scott W.; MANNOORI, Raju; MCDONALD, Ivar M.; OLSON, Richard E.; RAHAMAN, Hasibur; JALAGAM, Prasada Rao; ROY, Saumya; TONUKUNURU, Gopikishan; VELAIAH, Sivasudar; WARRIER, Jayakumar Sankara; ZHENG, Xiaofan; TOKARSKI, John S.; DASGUPTA, Bireshwar; REDDY, Kotha Rathnakar; RAJA, Thiruvenkadam; (0 pag.)WO2020/6018; (2020); A1;,
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