Month: January 2021

54699-92-2, 4-Methyl-1-piperazineacetic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,54699-92-2

Example 13; General Method For The Preparation Of Active Esters Of N-Substituted Piperazine Acetic Acid From Trifluoroacetate Esters; A solution of the trifluoroacetate in THF (0.58 M, 1.2 equiv) was added to a solid sample of N-methyl piperazine acetic acid and mixed in a vortex or shaker until a homogeneous solution was obtained. The reaction of the carboxylic acid with the trifluoroacetate ester was generally complete within 30 min for all cases except N-hydroypyrrolidinone (NHP, 18 h). The progress of conversion to the active ester was monitored by ES-MS. The amount of product and any starting material (N-MPA) could be determined by direct infusion of a sample of the reaction (in ethanol) into the ES-MS. In some cases the active ester product was precipitated as dihydrochloride salt by the addition of a solution by addition of HCl solution in dioxane (4 M, 50% volume of the reaction) followed by washing with THF, ethyl acetate and hexanes. In other cases the product was isolated from the reaction as the mono TFA salt. Addition of TFA could be performed if the bis-TFA salt was desired. Dhbt ester, Calculated MH+ = 304.14 Found = 304.20 NHP ester, Calculated MH+ = 242.15 Found = 242.20 4-NP ester, Calculated MH+ = 280.13 Found = 280.20 1H NMR (400 MHz, CDCl3) d 8.20 (d, 2H, J=9.2 Hz, aromatic protons), 7.25 (d, 2H, J=9.2 Hz, aromatic protons), 3.69-3.40 (broad, 2H, ring protons), 3.57 (s, 2H, -CH-CO-), 3.15-2.90 (broad, 6H, ring protons), 2.78 (s, 3H, -CH3). Pfp ester, Calculated MH+ = 325.10 Found = 325.10 Pcp ester, Calculated MH+ = 404.95 Found = 405.90 3-NP ester, Calculated MH+ = 280.13 Found = 280.20 NHS ester, Calculated MH+ = 256.13 Found = 256.10

54699-92-2 4-Methyl-1-piperazineacetic acid 2762732, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Applera Corporation.; US2005/148773; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

1.0 g of 1-(2,4-fluorophenyl)-piperazine (Compound A-1c), 15 mL of acetic acid was added to the sealed reactor, followed by the addition of 3 mL of hydrated formaldehyde, 1.0 g of sodium acetate;The reaction mixture was warmed to 60 C and stirred for 18 hours;The residue obtained was purified to give 1-(2,4-fluorophenyl)-4-methylpiperazine (A-c) (0.92 g, yield 86%)., 115761-79-0

As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference£º
Patent; Chengdu Ruizhi Chemical Co., Ltd.; Zhou Zhen; Zhu Mingkui; Li Kun; (9 pag.)CN109897014; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 9 (200mg, 0.8mmol), sodium iodine (289mg, 1.93mmol) and substituted amines (1.61mmol) in methanol (30mL) was stirred at 40C for 5h. After the reaction was completed (monitored by TLC), the solution was concentrated under vacuum. Then the crude residue was purified by column chromatography (dichloromethane/methanol), affording pure product 10.

208167-83-3, As the paragraph descriping shows that 208167-83-3 is playing an increasingly important role.

Reference£º
Article; Liang, Yu-Kun; Yue, Zhi-Zhou; Li, Jia-Xin; Tan, Cun; Miao, Ze-Hong; Tan, Wen-Fu; Yang, Chun-Hao; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 505 – 515;,
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169447-86-3, (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5 – Hybrid Analogs of Ureas and Carbamates; The synthesis of compounds of this embodiment is shown in FIGs. 14A through 14D. In this embodiment, the isoquinolinyl areas and carbamates were synthesized stepwise with a trichloroacetyl chloride., 169447-86-3

The synthetic route of 169447-86-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY; WO2008/79945; (2008); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

To n-butanol (2 mL) was added compound 4A-3 (30 mg, 0.135 mmol) and compound 5A-2 (47 mg, 0.135 mmol), and then p-toluenesulfonic acid (23.3 mg, 0.135mmol) was added under stirring. The mixture was heated to 100C and stirred for 5 hours. After TLC indicated the reaction was completed, the reaction mixture was concentrated under reduced pressure to give a crude product, which was further purified and isolated by column chromatography to obtain an off-white solid proudct, compound I-5 (59 mg, yield 81.8%). 1H NMR (400 MHz, cd3od) delta 9.09 (d, J=8.2 Hz, 1H), 8.33 (dd, J=4.3, 1.2 Hz, 1H), 8.09 (s, 1H), 7.54 (d, J=8.7 Hz, 1H), 7.48 (dd, J=8.7, 4.3 Hz, 1H), 6.67 (d, J=2.2 Hz, 1H), 6.54 (dd, J=8.7, 2.4 Hz, 1H), 3.89-3.73 (m, 4H), 3.27 (dd, J=9.3, 4.9 Hz, 4H), 2.89-2.73 (m, 4H), 2.49 (s, 3H), 1.30 (d, J=6.9 Hz, 6H). LCMS: t=0.662 min, 532.3 (M), 534.3 (M+1)., 122833-04-9

As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.

Reference£º
Patent; Humanwell Healthcare (Group) Co., Ltd.; WANG, Xuehai; XU, Yong; SHENG, Xijun; ZHANG, Xiaolin; XIA, Hangui; YANG, Zhongwen; YUE, Yang; HUANG, Lu; XIAO, Qiang; (80 pag.)EP3372594; (2018); A1;,
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Piperazines – an overview | ScienceDirect Topics

438049-35-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438049-35-5,N-Boc-3-Ethylpiperazine,as a common compound, the synthetic route is as follows.

Anhydrous DMF solution N’N- carbonyl diimidazole (468mg, 2.80mmol) of (2mL) was added dropwisetriethylamine (0.59mL, 4.20 mmol) and N- tert-butoxycarbonyl-3-ethylpiperazine (500mg, 2.33mmol) inanhydrous DMF (2mL) solution at room temperature in a sealed tube 30min, adding anhydrous methanol(12mL), 60 C the reaction 24h, the solvent was removed, a saturated sodium chloride solution (30 mL), ethyl acetate (15mL ¡Á 2) and the combined organic phases, Na 2 SO 4 dried over anhydrous solvent removedconcentrate was subjected to column chromatography (eluent: Petroleum ether / EtOAc (v / v) = 5/1), to give260mg of colorless liquid: 4-tert-butoxycarbonyl-2-ethyl-piperazine-1-carboxylate, yield: 40%.

As the paragraph descriping shows that 438049-35-5 is playing an increasingly important role.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(S)-l-Allyl 4-tert-butyl 2- (hydroxymethyl) piperazine-1 , 4- dicarboxylate (22) was prepared from amino alcoholhydrochloride 21’HCl, applying allyl chloroformate in CH2CI2 in the presence of aqueous NaHCO3 solution; as leading references cf. T. W. Greene, P. G. M. Wuts, Protective Groups in Organic Synthesis, 3rd edition, John Wiley & Sons, 1999;P.J. Kocienski, Protecting Groups, 3rd edition, Georg Thieme Verlag, 2005.Data of 22: Ci4H24N2O5 (300.4): LC-MS (method 9a): Rt = 1.70, 201 ([M+H]+). 1H-NMR (DMSO-d6): 5.90 (m, 1 H), 5.29 (qd, J = 1.7,17.3, 1 H), 5.18 (qd, J = 1.5, 10.5, 1 H), 4.81 (t, J = 4.9, 1 H), 4.53 (d-like m, J ca . 5.1, 2 H), 4.04-3.75 (br. m, 4 H), 3.39 (m, 2 H), 2.95-2.70 (br. m, 3 H), 1.40 (s, 9 H).

314741-40-7, The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; POLYPHOR AG; OBRECHT, Daniel; ERMERT, Philipp; OUMOUCH, Said; LACH, Franck; LUTHER, Anatol; MARX, Karsten; MOeHLE, Kerstin; WO2011/15241; (2011); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

Compound 63 (100 mg, 0.228 mmol) was dissolved in ultra dry THF. After adding N-cyclopropylpiperazine (144 mg, 1.14 mmol), Stir overnight at room temperature. The reaction was quenched by the addition of a small amount of water and extracted three times with dichloromethane. Washed three times with saturated brine, dried over anhydrous magnesium sulfate, filtered and evaporated. Column chromatography to give the title compound (Yellow solid, 37 mg), yield 31%., 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jianhua; Xu Yechun; Huang Fubao; Liu Qiufeng; Wang Kai; (79 pag.)CN109651208; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

278788-66-2, 2,6-difluoro-3-(oxiran-2-yl)benzonitrile (3.70 g, 20.4 mmol) and (R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (6.63 g, 30.6 mmol) were dissolved in ethanol (36.0 mL) then placed in 3-20mL sealed tubes andmicrowaved at 140C for 1 h. The solvents were evaporated and the combined residue was purified by chromatographythrough a 120g ISCO Redi-sep column with 50% to 100% ethyl acetate/hexane solvent system to yield thetitle compound LC-MS (IE, m/z): 398 [M + 1]+.

The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compound 6 (1.0 equiv) with catalytic equivalent KI was dissolved in freshly distilled DMF in an oven-dried round bottom flask. Different aliphatic amines (3.0 equiv) was added dropwise. The reaction mixture was stirred at room temperature for about 4h. After the reaction monitored by TLC was over, water was added to the reaction mixture under stirring, and the suspended mixture was filtered. The crude residue was purified by column chromatography on silica gel to obtain the final products.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Lijuan; Chen, Yong; Deng, Dexin; Liu, Kongjun; Pei, Heying; Tang, Minghai; Xue, Linlin; Yang, Tao; Yang, Zhuang; Ye, Haoyu; Zheng, Shoujun; European Journal of Medicinal Chemistry; vol. 197; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics