197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 4-(2,7-diazaspiro[4.4]non-2-yl)-6-(2,2,2-trifluoroethyl)pyrrolo[2, 1 -f][1 ,2,4]triazine hydrochloride (intermediate 122), 72.0 mg (0.166 mmol), and tert-butyl 4-(4- formylphenyl)piperazine-1-carboxylate (CAS 197638-83-8), 40.1 mg (0.138 mmol), in dichloromethane, 1.40 ml, and triethylamine, 63.0 pL (0.455 mmol), was stirred at room temperature for 30 minutes. Sodium triacetoxyborohydride, 87.8 mg (0.4 14 mmol), was added in portions. The reaction mixture was stirred at room temperature for 18 hours. The reaction was quenched with water and stirred at room temperature for 30 minutes. The product wasextracted into dichioromethane and the organics were dried over magnesium sulfate and concentrated under vacuum. The residue was by flash chromatography on silica gel 60 (eluent: ethyl acetate-5% ammonia/methanol 1:0, 9:1) to give the desired product, 84.0 mg (85%).LC-MS (method 13): Rt = 1.00 mm., 96%. MS (ESIpos): m/z = 600 [M+H].1H NMR (400 MHz, CDCI3): 6 [ppm] = 1.47 (s, 9H), 1.82-2.12 (m, 4H), 2.38-2.78 (m, 4H),3.07-3.14 (m, 4H), 3.36-3.42 (m, 2H), 3.54-3.57 (m, 6H), 3.62-4.00 (m, 4H), 6.66 (s, 1H), 6.85 (d, 2H), 7.20 (d, 2H), 7.50 (s, 1H), 7.81 (s, 1H)., 197638-83-8
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Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; SIEGEL, Stephan; HAENDLER, Bernard; STRESEMANN, Carlo; FERNANDEZ-MONTALVAN, Amaury, Ernesto; TER LAAK, Antonius; STOeCKIGT, Detlef; HARB, Hassan, Youssef; KOSEMUND, Dirk; EHEIM, Ashley; MOeNNING, Ursula; (234 pag.)WO2018/24602; (2018); A1;,
Piperazine – Wikipedia
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