The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
694499-26-8, Example 16: 6-[[6-(Amino)-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1 -piperazinyl)methyl]-3- (trifiuoromethyl)phenyl]-1-naphthalenecarboxamide; A solution containing ~50% of propylphosphonic anhydride in lambda/,lambda/-dimethylformamide (Fluka; 700 mul_, -1.1 mmol) is added to a stirred mixture of 6-[(6-amino-4-pyrimidinyl)oxy]-1- naphthalenecarboxylic acid (200 mg, 0.71 mmol), 4-[(4-methyl-1- piperaziny.)methyl]benzeneamine (194 mg, 0.71 mmol) and triethylamine (812 mul_, 6 mmol) in 10 mL lambda/./V-dimethylformamide. After stirring for 24 hours at 5O0C1 the mixture is treated with a saturated aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The combined extracts are dried (Na2SO4) and solvent is evaporated off under reduced pressure to give a residue, which is purified by column chromatography (SiO2; CH2CI2/MeOH/NH3(d 0.88) 90:9:1) and recrystallised from ethylacetate-hexane to afford the title compound as a pale-yellow solid, m.p.: 127-1300C.
The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; WO2008/125691; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics