With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.
A solution of 4-nitrobenzoyl chloride (25) (1 g, 5.39 mol) in CH3CN (50 mL) was treated with 1-methylpiperazine (26) at 10 C. over 10 min. The reaction mixture was stirred for another 1 h followed by addition of TEA (1.49 mL, 2 eq) and stirring for an additional half hour. The reaction mixture was diluted with ice-cold water (150 mL) and extracted with EtOAc (4¡Á150 mL). The organic layer was dried over MgSO4 and concentrated to give 1.1 g (82% yield) (4-methylpiperazin-1-yl)(4-nitrophenyl)methanone 27 as a yellow solid. TLC: 10% MeOH/DCM, Rf=0.6. 1NMR (400 MHz, CDCl3) 8.28(d, J=8.5 Hz, 2H), 7.56(d, J=8.5 Hz, 2H), 3.88(br-s, 4H), 3.46(br-s, 4H), 2.40(s, 3H) ESI/MS m/z 250.0 (M+H)
109-01-3, 109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; SUPERGEN, INC.; US2008/214558; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics