With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
2-chloro-7-(3-nitrophenyl)thieno[3,2-d]pyrimidine (6, 0.5 g, 1.7 mmol) and 2-methoxy-4-(4- methylpiperazin- l -yl)aniline (7, 0.34 g, 1.5 mmol) were taken up in 2,2,2 trifluoroethanol (5 mL) along with p-toluenesulfonic acid (p-TSA) (0.980 g, 5.1 mmol) to form a mixture. The mixture was heated at 150 C for 45 min in a microwave. The production of product 8 in the reaction mixture was monitored using LCMS. The reaction mixture was then basified with 0.5M NaOH (in CH3OH) and concentrated. Water was added to the resultant concentrate and the mixture was extracted in ethyl acetate, dried over Na2S04 and concentrated. The resultant concentrate was purified by column chromatography (Silica gel 10%CH3OH in DCM) to obtain a yellow solid of N-(2-methoxy-4-(4- methylpiperazin- l -yl)phenyl)-7-(3-nitrophenyl)thieno[3,2-d]pyrimidin-2-amine (8, 0.265 g, 32%). ‘HNMR (CDC13): 8.58-8.55 (d, 2H), 8.43-8.35 (dd, 2H), 8.30-8.25 (d, I H), 8.10 (s, I H), 7.70-7.63 (m, 2H), 6.58 (s, I H), 6.58 (s, I H), 3.90 (s, 3H), 3.24-3.18 (m, 4H), 2.72-2.65 (m, 4H), 2.40 (s, 3H), 122833-04-9
As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.
Reference£º
Patent; GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun; WO2011/79231; (2011); A1;,
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