170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
mCPBA (<77% pure) (8.8 mg, 0.039 mmol) in DCM (0.5 ml) was added to a stirred solution of 3-(8-methyl-2-(methylthio)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl acetate (11.6mg, 0.034 mmol) in toluene (1.0 mL) at RI under nitrogen. After 15 mi DIPEA (0.018 mL, 0.102 mmol) and tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (10.4 mg, 0.037 mmol) were added, successively, and the temperature was increased to 60 C. After 16 h, the reaction mixture wascooled to RI and was loaded directly onto a KP-NH column and purified by flash chromatography (0-100%, EtOAc in cyclohexane; then 10% MeOH in EtOAc) to give the title compound (9.7 mg, 54%) as a yellow solid. LCMS (MethodA) : RT = 1.25 mi m/z = 529 [M+H]. 170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; O’DOWD, Colin Roderick; BURKAMP, Frank; BELL, Mark Peter; WO2015/19037; (2015); A1;,
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