With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.
General procedure: The mixture of 2-amino-5-bromobenzoic acid (1.00 g,4.63 mmol), triethyl orthoformate (1.00 mL, 6.02 mmol), amine(6.02 mmol), iodine (0.12 g, 0.046 mmol) and anhydrous ethanol(20 mL) was refluxed under nitrogen atmosphere for 4-6 h, thenconcentrated under vacuum to give a residue which was dissolvedin ethyl acetate (90 mL). The ethyl acetate solution was washedwith 1 N aqueous sodium hydroxide (20 mL 3) and brine(30 mL 3), dried over anhydrous sodium sulfate and concentratedto give a white or light yellow solid.
70261-82-4, The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhang, Hao; Xin, Min-Hang; Xie, Xiao-Xiao; Mao, Shuai; Zuo, Sai-Jie; Lu, She-Min; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7765 – 7776;,
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