With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of amine 4 (1.82 g, 9.56 mmol) inDMF (20 mL) at 0 C was added K2CO3 (3.61 g, 26.13 mmol) followed by the addition of compound 3(1.96 g, 8.67 mmol) and the reaction mixture was stirred overnight at 60 C. After completion of thereaction (TLC analysis), the mixture was cooled to room temperature and diluted with ethyl acetate(75 mL). The solution was washed with H2O (30 mL ¡Á 3), brine (20 mL ¡Á 2) and the organic layer wasseparated, dried over Na2SO4 and evaporated under vacuum to afford the title compound 5 as as lightyellow amorphous solid (2.16 g, 74%), m.p. 196-197 C. IR (KBr): 3063, 2999, 2929, 2233, 1670,1622, 1596, 1578, 1457, 1430, 1389, 1341, 1294, 1249, 1155, 1094, 1072 cm-1. 1H-NMR (CDCl3): delta3.47 (br. s, 4H, -CH2NCH2-), 3.79 (br. s, 4H, -CH2NCH2-), 6.99 (dd, 1H, J = 2.6, 9.4 Hz, Ar-H), 7.14(d, 1H, J = 2.7 Hz, Ar-H), 7.40-7.48 (m, 5H, Ar-H), 8.19 (d, 1H, J = 9.5 Hz, Ar-H). 13C-NMR(CDCl3): delta 46.44, 46.84, 110.05, 115.66, 118.89, 126.93, 127.10, 127.79, 128.67, 130.33, 134.69,137.79, 153.10, 170.61. Anal. Calcd for C18H16N4O3: C, 64.28; H, 4.79; and N, 16.66. Found: C,64.22; H, 4.84; and N, 16.60.
13754-38-6, The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ba-Salem, Abdullah O.; Ullah, Nisar; Shaikh, M. Nasiruzzaman; Faiz, Mohamed; Ul-Haq, Zaheer; Molecules; vol. 20; 5; (2015); p. 7807 – 7819;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics