438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,438631-77-7
DIPEA (5.15 mL, 29.46 mmol) was added to 695 7-bromo-4,5,6-trichloro-3-nitroquinoline (3.5 g, 9.82 mmol) and 272 1-(tert-butyl) 3-methyl (R)-piperazine-1,3-dicarboxylate (4.8 g, 19.64 mmol) in 78 THF (50 mL) at rt. The resulting solution was stirred at 80 C. for 2 days. The solvent was removed in vacuo. The crude product obtained was purified by flash silica chromatography (0 to 20% 57 EtOAc in 148 petroleum ether) to afford 697 1-tert-butyl 3-methyl (3R)-4-(7-bromo-5,6-dichloro-3-nitroquinolin-4-yl)piperazine-1,3-dicarboxylate (1.95 g, 35%) as a red solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.44 (9H, s), 3.25-3.32 (3H, m), 3.50-3.60 (2H, m), 3.75-3.85 (2H, m), 3.98-4.04 (1H, m), 4.12-4.22 (2H, m), 7.80-7.95 (1H, m), 9.07 (1H, d); m/z: ES+ [M+H]+=563.
As the paragraph descriping shows that 438631-77-7 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics