20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
20327-23-5, Step 1 : 3-(4-Cyclopropyl-piperazin-1-yl)-6-(3-nitro-phenyl)-pyridazine: To a solution of 3-chloro-6-(3-nitro-phenyl)-pyridazine (10.0 g, 424 mmol) in n-BuOH (150 mL) was added 1 -cyclopropyl-piperazine (8.55 g, 678 mmol) and NH4CI (2.27 g, 424 mmol) and the mixture was stirred for 48 h at 800C. The solvent was removed under reduced pressure, and the residue was diluted with water. After alkalization with ammonia, the mixture was extracted with ethyl acetate. The extract was dried (Na2SO4) and concentrated to give 7.2 g of crude 3-(4-cyclopropyl-piperazin-1 -yl)-6-(3-nitro-phenyl)-pyridazine. 1H NMR (300 MHz, DMSO-c(6) delta 8.85 (s, 1 H), 8.45 (d, 1 H), 8.22 (d, 1 H), 8.1 1 (d, 1 H), 7.89- 7.66 (m, 1 H), 7.39 (d, 1 H), 3.69-3.65 (m, 4H), 2.80-2.76 (m, 4H), 1 .78-1.65 (m, 1 H), 0.54- 0.38 (m, 4H).
As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.
Reference£º
Patent; NOVO NORDISK A/S; WO2007/3604; (2007); A2;,
Piperazine – Wikipedia
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