112984-60-8, 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of 6-FIisoro-7-{4-[3-hydroxy-4-(2-methyl-5-iiitro- imida2o-l-yl)-buty|-piperazin-l-yi}-1 -niethyl-4-ox0-4H~2 hia-8b-a2a- cyclobiita[a]naphthaIeiie-3-carboxySic acid (116): To a stirred solution of 6- Fluoro- I -methyl-4-oxo-7-piperazin-l -yi-4H-2-thia-8b-aza- cycIobuta a]naphthalene-3-carboxyIie acid, (III) (3g, 8.6 mmol) in DMF (30ral) was added potassium carbonate ( S .20g, 8.6 mmol) followed by addition of compound (II) (2g, 7.2 mmol) and the reaction mixture was stirred at RT for 16h. The reaction mixture was diluted with ethyl acetate, washed twice with water and finally dried over sodium sulphate to obtain the crude mass. The crude was purified by flash column chromatography while eiuting with 3-5% methanol/dichloromethane mixture to obtain the pure compound (116) with 20% isolated yield. -NMR (400 MHz, DMSO) deltarhorhoetaiota: 1.61-1.68 (2H, m, CH2), 2.12 (3H, d, J = 6 Hz, CH3), 2.46 (3H, s, CH3), 2.57 (4H, m, 2 x CH2), 3.2 (4H, m, 2 x CH2), 3.8-4.1 (2H, m, 2 x’ CH2N), 4.44(1H, m, CHOH), 5.2 (1H, bs, CHOH), 6.4 (1H, q, Ji = 5.6Hz, J2 = 1 1.6Hz, CHSN) 6.91 (1 H, d, J = 7, Ar-H), 7.78 (1H, d, J= 13.6 Hz, Ar-H). 8.04 (I H, s, Ar-H). ESI-MS (m/z): 547.08(M+H)+., 112984-60-8
112984-60-8 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 124225, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; CHAWRAI, Suresh Rameshlal; GHOSH, Shamik; GHOSH, Sumana; JAIN, Nilu; SADHASIVAM, Suresh; BUCHTA, Richard; BHATTACHARYYA, Anamika; WO2015/114666; (2015); A2;,
Piperazine – Wikipedia
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