With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.
To a stirred solution of IV (0.100 g, 0.30 mmol), VI (0.095 g, 0.46 mmol) in DMF (2 mL) wasadded HATU (0.230 g, 0.61 mmol) and DIPEA (0.16 mL, 0.9 mmol) and reaction mixture was allowed tostir at RT for 16 h. Reaction mixture was diluted with water and extracted with ethyl acetate (10 mL x 3).Brine washing was given to the organic layer and dried over Na2SO4. Combined organic layer wasconcentrated under vacuum and purified by using reverse phase HPLC to obtain 3 (0.017 g, 11%).LCMS: 525 [M+1]+1HNMR (400 MHz,CD3OD) delta 8.3 (s, 1H), 8.0 (s, 1H), 7.9 (t, 2H), 7.8 (d, 1H), 7.7 (d, 2H),7.6 (m, 2H), 7.5(m, 2H), 7.4 (d, 2H), 7.1 (t, 1H), 3.6 (s, 2H), 2.8 (s, 4H), 2.6 (s, 4H), 2.5 (s, 3H), 2.4 (s, 3H), 70261-82-4
70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
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