13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A15. 1-(5-Bromo-pyridine-2-sulfonyl)-4-(2-methoxy-ethyl)-piperazine; 809 mg of 1-(2-methoxyethyl)-piperazine are dissolved in 9.0 ml of dichloromethane and 9.0 ml of an aqueous K2CO3 solution (strength 4.0 M). Subsequently, the reaction mixture is cooled in an ice bath and a solution of 1.20 g of 5-bromo-pyridine-2-sulfonyl chloride (compound B8) in 2.0 ml of dichloromethane is added dropwise. Thereafter, the reaction mixture is allowed to warm up to room temperature during which time the two-phase system is vigorously stirred for 1 hour. For workup, the organic layer is separated and the aqueous layer is extracted once with 10 ml of dichloromethane. The combined organic layers are dried, using Na2SO4, filtered with suction and evaporated to dryness to yield 1.70 g of the title compound as yellow oil, which crystallizes at room temperature. M. p. 940C. ESI- MS: 364.3/366.1 (MH+). TLC: Rf = 0.40 (dichloromethane/ethanol 20:1 parts by volume)., 13484-40-7
13484-40-7 1-(2-Methoxyethyl)piperazine 2734638, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ALTANA Pharma AG; WO2007/39578; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics