5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 17 4-({3-Chloro-4-[(1-ethyl-4,5-dimethyl-1H-imidazol-2-yl)sulfanyl]phenyl}amino)-7-[3-(4-ethyl-1-piperazinyl)propoxy]-6-methoxy-3-quinolinecarbonitrile To a stirred solution of 4-[3-chloro-4-(1-ethyl-4,5-dimethyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile (0.300 g, 0.539 mmol) in DMF (2 mL) was added 1-ethyl-piperazine (0.137 mL, 1.08 mmol) and NaI (0.008 g, 0.0539 mmol). The solution was heated to 100 C., maintaining the temperature overnight. The solution was cooled to room temperature and then diluted with brine (2 mL) and H2O (2 mL). The precipitate was collected via vacuum filtration and washed with H2O and Et2O to afford the product (0.290 g, 85%) as a solid, mp. 229-230 C.; 1H NMR (DMSO-d6) delta 0.93 (t, J=7.2 Hz, 3H), 1.04 (t, J=7.1 Hz, 3H), 1.85-1.95 (m, 2H), 2.07 (s, 3H), 2.15 (s, 3H), 2.22-2.43 (m, 12H), 3.86 (s, 3H), 3.90 (dd, J=7.1, 14.4 Hz, 2H), 4.14 (t, J=6.4 Hz, 2H), 6.58 (d, J=8.6 Hz, 1H), 7.06 (dd, J=2.3, 8.7 Hz, 1H), 7.29 (s, 1H), 7.30 (d, J=2.3 Hz, 1H), 7.61 (s, 1H), 8.45 (s, 1H), 9.46 (s, 1H); mass spectrum [(+) ESI], m/z 634/636 (M+H)., 5308-25-8
5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Wyeth; US2009/264427; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics