5294-61-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5294-61-1,N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
Part C. Synthesis of N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-4phenylbutanoyl) piperazinyl]acetamide (7) To a solution of 5 in 10ml DMF (0.263g, 1.07mmol) was added compound 6 (0.25g, 1.39mmol), HBTU (0.526g, 1.4mmol), triethylamine (0.108g, 1.07mmol) and DMAP (0.030g, 0.25mmol). The solution was allowed to stir at room temperature for 48h. The solution was concentrated in vacuo. The residue was taken into EtOAc (100ml) and washed with saturated sodium bicarbonate (3*50ml). The organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified using prep. TLC (10:1 DCM/MeOH) to afford compound 7: Mass spectrum (M+1)=410.44.
The synthetic route of 5294-61-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Blackburn, Brent K.; Zablocki, Jeff; Elzein, Elfatih; Nudelman, Grigory; US2001/44541; (2001); A1;,
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