78551-60-7, tert-Butyl 4-benzyl-3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
78551-60-7, Step 1: 1-Benzyl-4-(tert-butyloxycarbonyl)piperazin-2-thione A mixture of 1-benzyl-4-(tert-butyloxycarbonyl)piperazin-2-one (1.0 mg, 3.4 mmol) and 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulphide (Lawesson’s Reagent) (837 mg, 2.1 mmol) were heated at 90 C. in toluene (10 mL), under nitrogen for 45 min. The mixture was cooled then partitioned between EtOAc (3*50 mL) and water (50 mL). The combined organic layers were dried (Na2 SO4) and evaporated. The residue was chromatographed on silica gel, eluding with CH2 Cl2:EtOAc (100:0?95:5?90:10) to afford the title compound (853 mg, 82%) as a colourless solid. mp. 126-129 C. 1 H NMR (250 MHz, CDCl3) delta 1.47 (9H, s), 3.40-3.44 (2H, m), 3.60-3.65 (2H, m), 4.67 (2H, s), 5.31 (2H, s), 7.31-7.39 (5H, m). MS (ES+) (307, M+1).
As the paragraph descriping shows that 78551-60-7 is playing an increasingly important role.
Reference£º
Patent; Merck Sharp & Dohme Ltd.; US5998415; (1999); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics