With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8
To a solution of 4 (0.5g, 2.5mmol) in THF was added Et3N (0.52mL, 3.76mmol) and N-(2-aminoethyl)acetamide (0.25g, 2.5mmol). The mixture was stirred at 30C for 1h, cooled to room temperature and concentrated in vacuo. The residue was suspended in water and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated by evaporation in vacuo. Solid was recrystallized from toluene to afford 12. Recrystallized from acetonitrile as a white solid (55% yield).
As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.
Reference£º
Article; Bolteau, Raphael; Caignard, Daniel H.; Delagrange, Philippe; Descamps, Florian; Ettaoussi, Mohamed; Melnyk, Patricia; Yous, Said; European Journal of Medicinal Chemistry; vol. 189; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics