122323-88-0, Methyl piperazine-2-carboxylate dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1 -chloroisoquinoline, intermediate compound I0 (905 mg) was dissolved in CH3CN (72 ml). Potassium carbonate (796 mg) was added followed by piperazine-2-carboxylic acid methyl ester di-hydrochloride (1 .8 g). The mixture was stirred at 100C for 7 days. DCM was added and the mixture washed with water. The organic phase was separated, dried and evaporated by vacuum. The crude material was purified by Si-column eluting with cHex/Ethyl acetate 3:7 to ethyl acetate/MeOH 9:1 to obtain 570 mg of the methyl 4-(isoquinolin-1 -yl)piperazine-2-carboxylate, intermediate compound 11 (Y=38%). LC-MS (M-H+) = 272.2., 122323-88-0
As the paragraph descriping shows that 122323-88-0 is playing an increasingly important role.
Reference£º
Patent; AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.; OMBRATO, Rosella; GAROFALO, Barbara; MANGANO, Giorgina; CAPEZZONE DE JOANNON, Alessandra; CORSO, Gaia; CAVARISCHIA, Claudia; FURLOTTI, Guido; IACOANGELI, Tommaso; (161 pag.)WO2016/96686; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics