With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.
5308-25-8, To a solution of 5-chloro-2-nitroaniline (200 mg,1.16 mmol) in dry DMF (4 mL), K2CO3 (240 mg, 1.74 mmol) and compound47 (172 mg, 1.51 mmol) were added. The reaction mixture was heated to 110C for 12 h. Completion of reaction was observed by TLC (1:4/MeOH:CH2Cl2, Rf 0.70). Thereaction mixture was diluted with EtOAc (30 mL), washed successively with H2O (2¡Á30 mL)and brine (20 mL), then dried over MgSO4. The organic layer was removed under reducedpressure and the residue was purified by flash chromatography (SiO2, 1:19/MeOH:CH2Cl2) toafford compound 52 as a yellow solid (110 g, 38%)
The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chandrika, Nishad Thamban; Shrestha, Sanjib K.; Ngo, Huy X.; Garneau-Tsodikova, Sylvie; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3680 – 3686;,
Piperazine – Wikipedia
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