With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.350684-49-0,tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The adamantane-1-isocyanate (157 mg, 0.88 mmol) was dissolved in 5 mL of anhydrous dichloromethane. A solution of tert-butyl 4- (4-aminobenzoyl) piperazine-1-carboxylate (5) (270 mg) was added dropwise to a solution of 5 mL of anhydrous dichloromethane at 0 C, 0.88 mmol). The reaction was allowed to warm at room temperature and stirred overnight. After about 12 hours, the reaction was stopped, concentrated, and purified by column chromatography (CH2C12: CH30H = 40: 1) to give 320 mg of a white powder solid in 66% yield.
350684-49-0, The synthetic route of 350684-49-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chinese Academy of Sciences, Shanghai Institute of Medicine; LONG, YAQIU; HUANG, SHAOXU; (71 pag.)CN102464631; (2016); B;,
Piperazine – Wikipedia
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