With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1188265-73-7,tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Phenyl (4-chloro-3-fluorophenyl)carbamate (441 mg, 1.659 mmol) and tert-butyl 3-(2- hydroxyethyl)piperazine-l-carboxylate (382 mg, 1.659 mmol) were suspended in EtOH (5 niL) and heated in a Biotage Initiator using initial high setting to 100 C for 7 min. The reaction was concentrated under a stream of nitrogen at 50 C then dissolved in DCM (3 niL) and TFA (3 niL, 38.9 mmol). After 30 minutes the reaction was concentrated under a stream of nitrogen at 50 C. The residue was dissolved in DCM/MeOH and loaded onto a SCX-3 cartridge (2 g). The cartridge was washed with 3 volumes of MeOH, then eluted with 3 volumes of 2N NH3MeOH. The eluants were concentrated under a stream of nitrogen at 50 C followed by high vacuum, resulting in the isolation of N-(4-chloro-3-fluorophenyl)-2-(2 -hydro xyethyl)piperazine-l-carboxamide (494 mg, 1.637 mmol, 99 % yield) as a white solid.LC/MS (ESI): m/z 302.0 (M+H)+, 0.39 min (ret. time)
1188265-73-7, 1188265-73-7 tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate 53407692, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BAILEY, James; CHEN, Yao; HURLE, Mark; LEACH, Craig; TURUNEN, Brandon; (103 pag.)WO2018/134731; (2018); A1;,
Piperazine – Wikipedia
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