With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
mixture of 4-methyl-2-piperazinone (200 mg, 1.75 mmol), 4-iodoaniline (384 mg, 1.75 mmol), K3PO4 (848 mg, 4.00 mmol) and 1,2-trans-diaminocyclohexane (98 uL, 0.80 mmol) in dioxane (6 mL) was degassed with Ar before being charged with CuI (76 mg, 0.40 mmol). The mixture in a sealed tube was heated at 110 0C for 4 h. It was then purified by a silica gel prep-TLC using CH2C12/MeOH (95/5) as solvents to give the desired product (25 mg). MS 206.2 (M+H)., 34770-60-0
The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2006/55951; (2006); A2;,
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