With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-39-1,2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.
5521-39-1, To a solution of Example 7 compound 1b (313 mg, 1 mmol) and TFE (2,2,2-trifluoroethanol, 4 mL) was added 2-[4- (4-aminophenyl)piperazin-1-yl]ethanol (265 mg, 1.2 mmol) and TFA (trifluoroacetic acid, 342 mg, 3 mmol). The resulting mixture was heated to reflux and stirred overnight, then cooled to room temperature. EtOAc (50 mL) was added and the mixture was washed with saturated NaHCO3 (50 mL). The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to obtain the crude compound. Then purify with silica gel column, dichloromethane: methanol = 20: 1 rinse, after concentration to obtain the target compound 2o.
As the paragraph descriping shows that 5521-39-1 is playing an increasingly important role.
Reference£º
Patent; Guangdong University of Technology; Chen Huixiong; Yan Longjia; Li Yongliang; Chen Anchao; Deng Minggao; (30 pag.)CN110724137; (2020); A;,
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