With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.
Example 8 N- [3,3-Dimethyl -1- (4-methyl-piperazine-1-carbonyl) -2, 3- [ DIHYDRO-LH-INDOL-6-YL]-2- (4-FLUORO-BENZYLAMINO)-BENZAMIDE] Step A: Preparation of [N- [3, 3-DIMETHYL-L- (4-METHYL-] [PIPERAZINE-1-CARBONYL)-2, 3-DIHYDRO-LH-INDOL-6-YL]-2-NITRO-] benzamide [N- (3,] 3-dimethyl-2, [3-DIHYDRO-LH-INDOL-6-YL)-2-NITRO-] benzamide (Example 7, Step A) (300 mg, 0.96 mmol) was treated with [4-METHYL-PIPERAZINE-1-CARBONYL] chloride (200 mg, 1 mmol) in the presence of DIEA (40 mL) in THF overnight at 65 [C.] The mixture was partitioned between EtOAc and saturated aqueous [NAHC03.] The organic layer was washed with [H2O] and brine, then dried over [NA2SO4.] The organic solution was concentrated in vacuo to yield the desired compound., 39539-66-7
The synthetic route of 39539-66-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; WO2004/5279; (2004); A2;,
Piperazine – Wikipedia
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