With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.
50 ml of THF and 5 g (0.153 mol) of 1- hydroxyethylpiperazine are placed in a 500 ml three-necked flask equipped with a thermometer, a condenser and a bubbler, with magnetic stirring and under a stream of nitrogen. After cooling to 0¡ãC, 1.539 g (0.064 mol) of sodium hydride are added and this medium is stirred for 1 hour to obtain the alkoxide. A solution derived from 250 ml of THF and 4.3 g (0.028 mol) of 3-fluoro-4-nitroaniline is added dropwise to this alkoxide. The medium obtained is stirred for 24 hours while monitoring by TLC (9/1 CH2Cl2/MeOH). The solvent is removed by evaporation on a rotavapor, followed by purification on a column of silica, eluting with dichloromethane/methanol. The compound thus obtained in the form of a yellow powder, in a mass of 9.3 g, corresponds to the expected compound. Analysis by mass spectrometry confirms the structure of the expected compound. The quasi-molecular ions [M+H]+ and [M+Na] + of the expected molecule C13H20N4O3 are mainly detected.
5464-12-0, As the paragraph descriping shows that 5464-12-0 is playing an increasingly important role.
Reference£º
Patent; L’OREAL; FADLI, Aziz; WO2013/87934; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics