With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.
292To a solution of 1-137 (0.21 mmol, 0.10 g) in DCM (2 mL) is added l-methyl-piperazin-2-one hydrochloride (0.030 g , 0.26 mmol) followed by NaBH(OAc)3 (0.47 mmol, 0.10 g) and acetic acid (0.60 mmol, 0.035 mL). The mixture is stirred at room temperature for 6 days then concentrated under reduced pressure. The residue is purified by C18 reverse phase flash chromatography to provide 1-152 (0.044 g , 36%) as a clear film. To a suspension of 1-152 (0.076 mmol, 0.044g) in a 1 : 1 mixture of methanol : water (10 mL) is added LiOH (1.2 mmol, 0.050 g). The mixture is stirred at room temperature for 3 days during which time all of the solids went into solution. The pH of the mixture is then adjusted to approximately pH 5 by the addition of a 2N solution of hydrochloric acid and the mixture is concentrated under reduced pressure. The residue is purified by flash C18 reverse phase chromatography to provide the title compound (0.007 g, 16%) as a white powder., 109384-27-2
As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BERRY, Angela; BOSANAC, Todd; GINN, John David; HOPKINS, Tamara Denise; SCHLYER, Sabine; SOLEYMANZADEH, Fariba; WESTBROOK, John; YU, Maolin; ZHANG, Zhonghua; WO2013/25425; (2013); A1;,
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