With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-15-1,Methyl 1-Boc-piperazine-2-carboxylate,as a common compound, the synthetic route is as follows.
The compound N-1- t-butoxycarbonyl-2-piperazine-carboxylate (0.2g, 0.82mmol) and triethylamine (1.2mL,8.2mmol) was dissolved None Water tetrahydrofuran (5mL), at room temperature, to this solution was addeddropwise trimethylsilyl isocyanate (1.1mL, 8.2mmol), stirred at room temperature 8H, ice water (10 mL),tetrahydrofuran spin, the aqueous phase with ethyl acetate (10mL ¡Á 3). The organic phase was dried overanhydrous Na 2 SO 4 Drying, the solvent was removed, and concentrated to give 0.2g white solid: 2-methoxycarbonyl-4-carbamoyl-piperazine-1-carboxylate, yield: 90%.
129799-15-1, 129799-15-1 Methyl 1-Boc-piperazine-2-carboxylate 2756818, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
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