4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 8benzyl 2-(4-isopropylpiperazine-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate Oxalyl chloride (2.39 mL, 27.3 mmol) was slowly added to a solution of Intermediate 5 (2.77 g, 9.13 mmol) in DCM (70 mL) at 0¡ã C. under N2. One drop of DMF was added and the reaction mixture was stirred for 2 h. Oxalyl chloride (1.59 mL, 18.2 mmol) was added and the reaction mixture was stirred for 1 more hour. The solvent was concentrated under vacuum and the residue was recovered in DCM (30 mL). The resulting solution was added to a solution of 1-isopropylpiperazine (1.171 g, 9.13 mmol) and Et3N (6.36 mL, 45.66 mmol) in DCM (150 mL) at 0¡ã C. The reaction mixture was stirred for 1 h. The solvent was concentrated and the product was purified on silica gel by MPLC using 3percent-5percent MeOH in DCM as eluent to provide title compound (1.810 g, 47.9percent) as a gum. 1H NMR (400 MHz, CDCl3) delta ppm 1.03 (d, J=6.25 Hz, 6H) 1.52 (br. s., 2H) 1.61 (br. s., 2H) 1.94-2.07 (m, 2H) 2.08-2.18 (m, 2H) 2.39-2.52 (m, 4H) 2.70 (quintet, J=6.54 Hz, 1H) 3.18 (qd, J=8.66, 8.40 Hz, 1H) 3.29-3.40 (m, 4H) 3.40-3.49 (m, 2H) 3.57-3.65 (m, 2H) 5.11 (s, 2H) 7.28-7.42 (m, 5H); MS m/z 414.3 [M+H]+ (ESI).
4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; US2010/130477; (2010); A1;,
Piperazine – Wikipedia
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