697305-48-9, 1-(4-Fluorophenyl)piperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
697305-48-9, A mixture of 3-chloro-6-(3-furanyl)-8-(trifluoromethyl)imidazo[1 ,2-a]pyridine- 2-carboxylic acid potassium salt (0.107 g, 0,290 mmol), 1-(4-f.uorophenyl)-2-piperazinone hydrochloride (0.067 g, 0.290 mmol), DIPEA (0.152 mL, 0.871 mmol) and HATU (0.133 g, 0.349 mmol) in DMF (2 mL) was stirred at room temperature for one hour. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried over sodium sulfate and concentrated. The residue was purified by reverse phase HPLC (acetonitrile:water with 0.1 % formic acid) to give the title compound (0.059 g, 36%) as an off-white solid. H NMR (400 MHz, DMSO-c/6) delta ppm 8.71 – 9.06 (m, 1 H) 8.58 (s, 1 H) 8.08 – 8.33 (m, 1 H) 7.86 (s, 1 H) 7.40 – 7.48 (m, 2 H) 7.35 (s, 1 H) 7.26 (t, 2 H) 4.68 (s, 1 H) 4.42 (s, 1 H) 4.22 (br. s., 1 H) 4.05 (br. s., 1 H) 3.76 – 3.89 (m, 2 H). ES-LCMS m/z: 507 (M+ ).
697305-48-9 1-(4-Fluorophenyl)piperazin-2-one hydrochloride 67085022, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; PEAT, Andrew, James; PRICE, Daniel, J.; SHOTWELL, John, Brad; TAI, Vincent; ZHANG, Huichang; WO2011/41713; (2011); A2;,
Piperazine – Wikipedia
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