With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of (3R,55)-tert-butyl 3,5-dimethylpiperazine-1 -carboxylate (2 g, 9 mmol) in DMF (20 mL) was added benzyl (2-bromoethyl)carbamate (3.2 g, 11 mmol), K2C03 (2.5 g,18 mmol) and Nal (1.0 g). The reaction was stirred at 70-80 C for 24 h, cooled to room temperature, and poured into water (60 mL). The reaction mixture was extracted with ethyl acetate, and the organic layers were combined, washed with brine, dried (Na2504), filtered, and evaporated. The crude residue was chromatographed (silica gel, DCM : MeOH = 20: 1) to afford (3R,5 5)-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)ethyl)-3 ,5 -dimethylpiperazine- 1-carboxylate as a yellow oil (2.2 g, 60%)., 129779-30-2
As the paragraph descriping shows that 129779-30-2 is playing an increasingly important role.
Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth A.; VERNER, Erik; WO2014/182829; (2014); A1;,
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