Application of 139755-85-4, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, belongs to piperazines compound. In a article, author is Sirakanyan, Samvel, introduce new discover of the category.
Synthesis and antimicrobial activity of new 2-piperazin-1-yl-N-1,3-thiazol-2-ylacetamides of cyclopenta[c]pyridines and pyrano[3,4-c]pyridines
In this study, we report the synthesis and antimicrobial activity of some new disubstituted piperazines. Thus, 3-chlorocyclopenta[c]pyridines and 6-chloropyrano[3,4-c]pyridine1under mild reaction conditions with piperazine gave the 3(6)-piperazine-substituted cyclopenta[c]pyridines and pyrano[3,4-c]pyridine2. Furthermore, the latter, by alkylation with 2-chloro-N-1,3-thiazol-2-ylacetamide, led to the formation of the target compounds. The evaluation of the antibacterial activity revealed that3kwas the most potent compound. The most sensitive bacterium was found to beListeria monocytogenes, whereasStaphylococcus aureuswas the most resistant one. Three compounds,3d,3g, and3k, were tested also against the following resistant strains: methicillin-resistantS. aureus(MRSA),Escherichia coli, andPseudomonas aeruginosa. All three compounds appeared to be more potent than ampicillin against MRSA. Moreover, compound3dshowed a better activity than the reference drug ampicillin againstP. aeruginosa, whereas3gwas more efficient againstE. coli. The best antifungal activity was observed again for compound3k. The most resistant fungi appeared to beAspergillus fumigatus, whereasTrichoderma virideseemed the most sensitive one toward the compounds tested. Molecular docking studies onE. coliMurB, as well as onCandida albicansCYP51 and dihydrofolate reductase, were used for the prediction of the mechanisms of the antibacterial and antifungal activities, confirming the experimental results.
Application of 139755-85-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 139755-85-4.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics