The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, SMILES is O=S(CCN1CCN(CCS(=O)(O)=O)CC1)(O)=O, in an article , author is Wright, Stephen W., once mentioned of 5625-37-6, Formula: C8H18N2O6S2.
Reduction of 2-hydroxy-3-arylmorpholines to 3-aryl morpholines
2-Hydroxy-3-aryl morpholines are readily prepared from arylboronic acids, aqueous glyoxal, and 1,2-aminoethanols by a variant of the Petasis borono-Mannich reaction. We now show that the 2-hydroxy-3-aryl morpholines may be deoxygenated to 3-aryl morpholines by treatment with methanesulfonic anhydride and triethylamine to afford intermediate 3,4-dihydro-2H-1,4-oxazines, followed by reaction with a triacetoxyborohydride salt and acetic acid to afford 3-aryl morpholines. This reaction sequence constitutes a three step, two pot preparation of 3-aryl morpholines from readily available starting materials (1,2-aminoethanols, arylboronic acids, and glyoxal) with excellent functional group tolerance and adaptability to scale. (C) 2020 Elsevier Ltd. All rights reserved.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics