Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, in an article , author is Howard, Zachary P., once mentioned of 5294-61-1, Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.
Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone
Coxiella burnetii is a zoonotic bacterial obligate intracellular parasite and the cause of query (Q) fever. During natural infection of female animals, C. burnetii shows tropism for the placenta and is associated with late-term abortion, at which time the pathogen titer in placental tissue can exceed one billion bacteria per gram. During later stages of pregnancy, placental trophoblasts serve as the major source of progesterone, a steroid hormone known to affect the replication of some patho-gens. During infection of placenta-derived JEG-3 cells, C. burnetii showed sensitivity to progesterone but not the immediate precursor pregnenolone or estrogen, another major mammalian steroid hormone. Using host cell-free culture, progesterone was determined to have a direct inhibitory effect on C. burnetii replication. Synergy between the inhibitory effect of progesterone and the efflux pump inhibitors verapamil and 1-(1-naphthylmethyl)-piperazine is consistent with a role for efflux pumps in preventing progesterone-mediated inhibition of C. burnetii activity. The sensitivity of C. burnetii to progesterone, but not structurally related molecules, is consistent with the ability of progesterone to influence pathogen replication in progesterone producing tissues.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 5294-61-1, you can contact me at any time and look forward to more communication. Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics