57184-25-5, 1-(Cyclopropylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57184-25-5
First, 5-amino-2-(2-furyl)[1,2,4]triazolo[1,5-c]pyrimidine-7-carboxylic acid (500 mg, 2.04 mmol) produced in Example 77 was dissolved in DMF (50 mL), and 4-cyclopropylmethylpiperazine (429 mg, 3.06 mmol), 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide monohydrochloride (782 mg, 4.08 mmol), and 1-hydroxybenzotriazole (312 mg, 2.04 mmol) were added to the resulting solution, followed by stirring at room temperature for 12 hours. Then, THF (30 mL), acid chloride resin [3.0 g, the acid chloride resin being prepared by the method described in the document (Tetrahedron Letters, Vol. 37, No. 40, p. 7193 (1996))] and polyvinylpyridine resin (produced by Aldrich Co., 3.0 g) were added to the reaction solution, followed by further stirring at room temperature for 12 hours. The resins were filtered off from the reaction solution, and the filtrate was concentrated. The residue was recrystallized from a mixed solvent of ethanol (10 mL) and DMF (10 mL) to obtain Compound 96 (420 mg, 1.14 mmol) as white crystals in a yield of 56%.1H NMR (delta ppm, DMSO-d6): 8.18 (brs, 2H), 7.95 (d, J=1.7 Hz, 1H), 7.22 (d, J=3.3 Hz, 1H), 7.00 (s, 1H), 6.73 (dd, J=3.3 Hz, 1.7 Hz, 1H), 3.50-3.65 (m, 2H), 3.40-3.45 (m, 2H), 2.40-2.50 (m, 4H), 2.21 (d, J=6.6 Hz, 2H), 0.83 (m, 1H), 0.43-0.49 (m, 2H), 0.06-0.08 (m, 2H) Mass (m/z): 368 (M++1) IR (KBr, cm-1): 1656, 1641, 1633, 1616, 1610, 1558, 1003 [] Elemental Analysis: as C18H21N7O2¡¤0.4 H2OObservedC 57.56%,H 5.95%,N 26.59%CalculatedC 57.71%,H 5.87%,N 26.17%Melting point: 299.2 – 299.8C
As the paragraph descriping shows that 57184-25-5 is playing an increasingly important role.
Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1544200; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics