A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 139755-85-4, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S. In an article, author is Casalone, Enrico,once mentioned of 139755-85-4.
1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps inEscherichia coli
Aim:To investigate the action mechanism of 1-benzyl-1,4-diazepane (1-BD) as efflux pump inhibitor (EPI) inEscherichia colimutants: Delta acrABor overexpressing AcrAB and AcrEF efflux pumps.Materials & methods:Effect of 1-BD on: antibiotic potentiation, by microdilution method; membrane functionality, by fluorimetric assays; ethidium bromide accumulation, by fluorometric real-time efflux assay; AcrB expression, by quantitative photoactivated localization microscopy.Results:1-BD decreases the minimal inhibitory concentration of levofloxacin and other antibiotics and increase ethidium bromide accumulation inE. colioverexpressing efflux pumps but not in the Delta acrABstrain. 1-BD increases membranes permeability, without sensibly affecting inner membrane polarity and decreasesacrABtranscription.Conclusion:1-BD acts as an EPI inE. coliwith a mixed mechanism, different from that of major reference EPIs.
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Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics