Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is , belongs to piperazines compound. In a document, author is Xie, Yu, Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.
Scaling up microreactors for kilogram-scale synthesis of piperacillin: Experiments and computational fluid dynamics simulations
In this study, two membrane dispersion microreactors in series are used to synthesize piperacillin with low impurity content in kilogram scale. By combining experiments and computational fluid dynamics simulations, the membrane size and cross-sectional area are scaled up from 2 mm x 0.7 mm and 2 mm x 1 mm to 6.5 mm x 2.5 mm and 6.5 mm x 3.5 mm, respectively, and the reaction time is extended from similar to 10 to similar to 60 min, which achieves that the synthesis scale of each batch is increased from 15 g to 1 kg. Subsequently, the effects of distance between ammonia feed and 4-ethyl-2,3-dioxo-1-piperazine carbonyl chloride feed, pH, circulation flow rate, and dispersed phase flow rate on solution concentration are discussed. The final piperacillin product with an average yield of similar to 94.70%, a purity exceeding 99.7%, the impurity D content similar to 0.077% and E content similar to 0.045%, satisfies the requirements of pharmacopeia regarding antibiotic impurities.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5625-37-6, in my other articles. Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics