Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a document, author is El Abbouchi, Abdelmoula, introduce the new discover, Computed Properties of C14H21N3O.
Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents
A series of ethacrynic acid (2-[2,3-dichloro-4-(2- methylidenebutanoyephenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC50, in the micromolar range (less than 4 uM). Three derivatives 6b, 7 b and 7 e were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRCS as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker’s best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5294-61-1 is helpful to your research. Computed Properties of C14H21N3O.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics