In an article, author is Kuang, Lu, once mentioned the application of 130307-08-3, Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, molecular weight is 255.1542, MDL number is MFCD09029689, category is piperazines. Now introduce a scientific discovery about this category.
One-pot, two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazoles
A facile, one-pot two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazole derivatives has been developed. The protocol employs an N-allylation of N-propargylated amines with 2,3-dibromopropene in the presence of K2CO3 in DMSO and a CuI-catalyzed [3 + 2] cycloaddition reaction of the synthetic N-(2-bromoallyl)-N-propargyl amines with sodium azide sequentially. Such a method provides methylene-substituted 1,2,3-triazole fused piperazines with some advantages such as simple operation, high efficiency and good product yield (80-91%) through readily available starting materials.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics